Efficacy of a Dermatopoietin-containing cosmetic composition was evaluated in double-blind placebo-controlled dermatological studies in the Skin Test Institute, Neuchatel, Switzerland.

The product was applied for eight weeks on a forearm of volunteers and a series of tests was made.

Results:
(i) The Dermatopoietin-containing product dramatically increased the collagen and elastin production in skin (see Fig. 1 and 2).

Figure 1. A, Real ultrasonogram of forearms of a volunteer at days 0, 28, and 56 of the cosmetic treatment. Arrows indicate dark pixels. Dark pixels represent low echogenic areas such as water and fat. Bright pixels represent fibrous network consisting of proteins such as collagen, elastin, and keratins. B, Reduction of mean Number of Dark Pixels (NDP) during the eight weeks of the cosmetic treatment (n = 21).

Figure 2. Real ultrasonograms of forearms of 3 volunteers are presented for days 0, 28, and 56 of the cosmetic treatment with a Dermatopoietin-containing composition.  Dark pixels represent low echogenic areas such as water and fat. Bright pixels represent fibrous network consisting of proteins such as collagen, elastin, and keratins.

 

(ii) elasticity of skin impaired by aging: it increased gross elasticity and decreased the viscoelastic portion. Decreased gross elasticity with an increased viscoelastic portion are typical signs of aged skin. Dermatopoietin had thus a clear anti-aging effect (see Fig. 3).

(iii) Dermatopoietin showed skin moisturizing effects (see Fig. 4).

Figure 3. A, Plot of the evolution of R2, gross elasticity, as difference between Dermatopoietin and Placebo group.  B, Plot of the evolution of mean R6, the viscoelastic portion of elasticity, as  difference between Dermatopietin and Placebo groups.

  

 

Figure 4. Plot of the evolution of mean skin moisture in the Dermatopoietin group.